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What Is Leukoplakia?

Leukoplakia is a condition in which thick, white patches or lesions appear within the mouth — typically on the gums or inside the cheeks — and is caused by excess cell growth. The sores can vary in appearance but are typically white or grey, and have thick, raised edges with a hard surface. These lesions usually appear within the mouths of smokers or users of smokeless tobacco, but they can also be a symptom of poorly fitting dentures or a sign of someone who habitually chews on the inside of their cheek.

Leukoplakia Signs and Symptoms

While not normally dangerous (most patches are considered benign), a small percentage of leukoplakia instances show early signs of mouth cancers appearing next to the growths. If you notice a sudden blossoming of these growths within your mouth, you should immediately contact your dentist for advice and treatment.

Other symptoms include grey patches that cannot be wiped or scraped away, areas that are irregular or flat-textured (as well as those that may feel thickened or have hardened), or even the appearance of raised, red lesions (called erythroplakia), which are the most likely to indicate precancerous changes occurring in the mouth.


Hairy Leukoplakia

There is another form called hairy leukoplakia that, like oral thrush, affects those with weakened immune systems more adversely. Hairy leukoplakia creates fuzzy, white patches that can be mistaken for oral thrush. Hairy leukoplakia is a result of infections stemming from the Epstein-Barr virus (EBV), which remains in the body for your lifetime. While normally dormant, the virus can be activated (or reactivated) due to the weakening of the immune system.

Parts of the population living with HIV/AIDS are far more likely to develop this type of leukoplakia because of their immunity deficiencies. According to Johns Hopkins, as many as 25 per cent of HIV-positive people are affected by hairy leukoplakia. Its appearance may mean one of two things — that HIV is spreading within the body or that their antiretroviral therapy is losing its efficacy in fighting on behalf of the weakened immune system.

While it’s not painful and might not lead to cancer, hairy leukoplakia still may indicate an HIV infection or AIDS. Even once the patches of leukoplakia have been removed, there is still a risk of experiencing some type of oral cancer in the future, so it’s best to remain vigilant about your mouth’s environment until your dentist has given you the all-clear.

Talk to Your Dental or Medical Specialist About Leukoplakia

If you think you see evidence of leukoplakia, consider a visit with your dentist or primary care physician. It’s possible you may also be referred to an oral surgeon (or otolaryngologist) to be diagnosed and receive treatment.

Testing and Diagnosing

Diagnosing leukoplakia involves your dentist or medical professional first examining your mouth and ruling out any and all other possible causes. Your dentist or medical professional will rule out early signs of cancer, which may include:

  • Tissue Sample for Biopsy — A small piece of tissue will be removed from any one of the lesions and will be sent out for testing.
  • Lab Analysis of Tissue — The testing lab will have a pathologist inspect and examine the piece of tissue for abnormal cells (carcinoma) that have appeared.
  • Excisional Biopsy — An excisional biopsy will occur if initial tests come back positive. In this instance, your dentist or oral surgeon will remove one of the lesion patches in full (if it’s small) or send you to an oral surgeon for one that’s larger and may require a more skilled hand.

Treating Leukoplakia

You doctor may recommend treating Leukoplakia by two types of medications: systemic and topical.

A systemic medication, they will prescribe an antiviral medication like Valtrex or Famvir. While the virus that causes leukoplakia never leaves the body, its spread can be halted. Regular treatment can clear up the leukoplakic patches, but they may return without regular treatment.

If your dentist recommends a topical medication, you could be dealing with a podophyllum resin solution or a retinoic acid. Both are applied topically to the patches, but as with systemic treatments, the patches can return if the topical medications aren’t used regularly and consistently.

If you recognize the signs or symptoms of leukoplakia in your mouth, contact your dentist or primary care physician so you can start getting the proper treatment to keep leukoplakia at bay.